Video shows a massive fireball and smoke after UPS Flight 2976 crashed into a Kentucky Petroleum Recycling building during takeoff at the Louisville airport.

A UPS cargo plane crashed at a Louisville, Kentucky, airport where the company operates its largest package delivery hub. UPS calls the giant center Worldport.

A third business, Packsize, also announced its intentions to undergo a nearly $30 million investment in Louisville. Here's what to know about the upcoming projects: AS UPS leans into its expansive healthcare enterprise in the metro, more companies are heading to Louisville to set up healthcare operations.