Captured mid-reaction, RNA polymerase reveals universal blueprint for gene transcription

The enzyme RNA polymerase (RNAP) carries out transcription, copying DNA into RNA. It's the first step in gene expression, and ...

Cancer cells can rewrite RNA messages, creating new drug targets in aggressive tumors

Scientists have uncovered an unexpected way cells can generate cancer-driving proteins—by cutting RNA into shorter, ...
UC San Diego Today

Water Molecules Found to Actively Drive Gene Transcription Process

Water molecules play an active, essential role in gene transcription, helping RNA polymerase II carry out the chemical steps ...
The Scientist

Water Molecules Play a Vital Role in Gene Transcription

EM, researchers showed that water mediates catalysis and important protein interactions for RNA polymerase II function in ...
Fred Hutch

Conducting RNA reconnaissance

Fred Hutch researchers invent a CRISPR screening method to understand RNA-binding proteins often mutated in cancer and other diseases In biology’s standard tale of two acids — deoxyribonucleic (DNA) ...

Blocking a cellular inflammation process could result in effective therapy for pancreatic cancer

Scientists at The Wistar Institute and clinical researchers from ChristianaCare's Helen F. Graham Cancer Center & Research Institute have discovered a vulnerability in pancreatic cancer that could be ...
News Medical

Elegen and Nutcracker Therapeutics to pilot first fully cell-free manufacturing process for RNA-based personalized cancer therapeutics

Elegen, a global leader in next-generation DNA manufacturing, and Nutcracker Therapeutics, a global leader in next-generation RNA design and manufacturing, today announced the launch of a pilot ...
The Conversation

MicroRNA − a new Nobel laureate describes the scientific process of discovering these tiny molecules that turn genes on and off

The 2024 Nobel Prize in physiology or medicine goes to Victor Ambros and Gary Ruvkun for their discovery of microRNA, tiny biological molecules that tell the cells in your body what kind of cell to be ...
Technology Networks

Improving RNA Purity and Measurement for Reliable Bioprocessing

This webinar explores practical strategies to reduce immunogenicity and improve RNA quality across manufacturing workflows.
GEN

Direct RNA Sequencing Supports Novel Discoveries in RNA Biology

Years of experiments and databases filled with RNA-seq results belie the simple reality that, until fairly recently, it was impossible to analyze RNA directly. The RNA-seq studies performed with ...