Tonight's Sunday Night Football game features an AFC thriller as the New England Patriots take on the Buffalo Bills. Live coverage begins at 7 PM ET.

Rounding out the afternoon in the late window for Week 5 will be Tennessee at Arizona, Detroit in Cincinnati, taking on the Bengals, and Washington visiting the West Coast to face the Los Angeles Chargers. It's Week 5, and the NFL is down to its final two undefeated teams in the Eagles and Buffalo Bills.

Some of the site's predictions differ from NFL Week 5 odds and other NFL Week 5 picks for NFL Week 5 games. How correct will the analytics be this week? Click on each game for more NFL Week 5 predictions for that NFL matchup. All times MST. The site allows for the possibility of ties, so the numbers add up to just less than 100%.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model is on a sizzling 43-28 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.

The Baltimore Ravens are limping into a Week 5 matchup with the visiting Houston Texans, missing five All-Pro players. Quarterback Lamar Jackson, linebacker Roquan Smith, and safety Kyle Hamilton are all out for Sunday's game with hamstring injuries.