In this study, the duration of enzyme induction provoked by unlabelled lactose ureide (LU) in orocaecal transit time (OCTT) measurements with lactose-[13 C]ureide (13 C-LU) was evaluated. Without ...

A team of mathematicians and pharmaceutical scientists collaborated to identify the major cause of the low accuracy of the equation in the FDA guidance used to predict drug-drug interaction through an ...

PNAS is the world's most-cited multidisciplinary scientific serial. It publishes high-impact research reports, commentaries, perspectives, reviews, colloquium papers, and actions of the Academy. In ...

Drugs are metabolized in the liver using several enzyme-catalyzed processes. These enzymes are collectively referred to as the hepatic microsomal enzyme system, and they are usually present in the ...

Malcolm C. Drew Fructose-1,6-bisphosphate aldolase (ALD) and enolase (ENO) from the glycolytic pathway, and pyruvate decarboxylase (PDC) and alcohol dehydrogenase 2 (ADH2) from the ethanolic ...

Researchers Explore a Number of Strategies to Better Predict Drug Responses in the Clinic As drug development costs continue to escalate, determining toxicity and possible interactions with foods, ...